Preheat oven to 350 degrees Fahrenheit (175 degrees Celsius) and line a rimmed baking sheet with parchment paper lightly coated with non-stick spray.
Combine cottage cheese, eggs, garlic powder, dried oregano, and black pepper in a high-speed blender or food processor.
Blend on high until the mixture is completely smooth and liquid with no visible curds.
Pour the batter onto the prepared baking sheet and spread with a spatula into a rectangle or circle approximately 1/4 inch thick.
Bake the crust for 35 to 40 minutes until the edges are deep golden brown and the center is set and firm to the touch.
Remove from the oven and allow the crust to cool on the pan for at least 10 minutes; this step is critical for the structural integrity of the flatbread.
Spread pizza sauce over the cooled crust and sprinkle evenly with mozzarella cheese and pepperoni slices.
Return to the oven for 5 to 7 minutes, or until the cheese is melted and bubbly, then let rest for 5 minutes before slicing.