Preheat oven to 375 degrees Fahrenheit (190 degrees Celsius).
In a medium mixing bowl, stir together the cottage cheese, marinara sauce, dried oregano, and garlic powder until well combined.
Transfer the mixture into a 6-inch oven-safe skillet or a small baking dish.
Spread the shredded mozzarella cheese evenly over the cottage cheese mixture.
Arrange the mini pepperoni slices on top of the mozzarella.
Sprinkle the Parmesan cheese and red pepper flakes over the top.
Bake in the preheated oven for 15 to 20 minutes, or until the cheese is melted and the edges are bubbling.
Optional: Place under the broiler for 1 to 2 minutes to brown the cheese.
Remove from oven and let sit for 5 minutes to set before serving.