Preheat oven to 400°F (204°C) and line a baking sheet with parchment paper.
In a large mixing bowl, combine self-rising flour and Greek yogurt until a dough forms.
Knead the dough on a lightly floured surface for 2 minutes until smooth and elastic.
Roll the dough into a large rectangle approximately 1/4 inch thick.
Spread pizza sauce over the dough, leaving a 1/2 inch border on all sides.
Evenly distribute mozzarella cheese and turkey pepperoni slices over the sauce.
Sprinkle with oregano and garlic powder.
Roll the dough tightly into a cylinder starting from the long edge.
Slice the cylinder into 12 equal rolls using a sharp knife.
Place rolls onto the baking sheet and brush the surfaces with the beaten egg.
Bake for 15 to 18 minutes until the crust is golden brown.
Rest for 5 minutes before serving.