Brown the ground beef in a large skillet over medium-high heat for 7-9 minutes until fully cooked.
Add salt, pepper, garlic powder, and onion powder to the beef, stirring to combine, then drain excess fat.
Whisk together the Greek yogurt, mustard, ketchup, and pickle juice in a small bowl until smooth.
Divide the chopped romaine lettuce into four separate meal prep containers or bowls.
Layer the cooked beef, tomatoes, red onion, and pickles over the lettuce.
Sprinkle shredded cheddar cheese evenly over the four servings.
Drizzle with the prepared sauce immediately or store sauce separately for consumption.