Preheat the oven to 375°F (190°C) and lightly coat a 9x13 inch baking dish with non-stick spray.
Cook the high-protein pasta in a large pot of boiling salted water for approximately 2 minutes less than the package instructions to achieve a firm al dente texture.
In a high-speed blender, combine the cottage cheese, Greek yogurt, Parmesan cheese, minced garlic, oregano, salt, and pepper. Blend until the mixture is completely smooth and creamy.
Drain the pasta and return it to the pot. Add the cubed chicken, the blended sauce, and the chicken broth.
Stir the ingredients over low heat for 1-2 minutes until the sauce is evenly distributed and the mixture is well-incorporated.
Transfer the pasta mixture into the prepared baking dish, spreading it into an even layer.
Top the casserole with the shredded mozzarella cheese.
Bake for 25 to 30 minutes, or until the sauce is bubbling and the cheese topping is golden brown.
Remove from the oven and allow the dish to rest for 5 minutes to set the sauce before portioning.