Place the cottage cheese into a microwave-safe bowl.
Stir the garlic powder and dried oregano into the cottage cheese until evenly distributed.
Spread the marinara sauce in a uniform layer over the top of the cottage cheese base.
Distribute the shredded mozzarella cheese evenly over the marinara sauce.
Arrange the pepperoni slices and red pepper flakes on top of the cheese layer.
Microwave on high for 60 to 90 seconds, or until the mozzarella is fully melted and bubbly.
Allow the bowl to rest for 60 seconds to let the temperature equalize before serving.