Preheat the oven to 400°F (204°C) and line a baking sheet with parchment paper.
In a large mixing bowl, whisk together the self-rising flour, unflavored protein powder, and garlic powder.
Fold in the shredded cheddar cheese and diced ham until evenly distributed throughout the dry ingredients.
Add the Greek yogurt to the center of the bowl and stir with a spatula until a shaggy dough forms.
Turn the dough onto a lightly floured surface and gently pat it down to a 1-inch thickness (do not overwork the dough).
Using a 2.5-inch biscuit cutter, cut out 8 rounds and place them on the prepared baking sheet.
Bake for 18 to 22 minutes, or until the tops are golden brown and the internal temperature reaches approximately 200°F.
Remove from the oven and immediately brush the tops with melted butter.